Docking Studies Show That D-Glucose and Quercetin Slide through the Transporter GLUT1
نویسندگان
چکیده
منابع مشابه
GLUT1 deficiency and other glucose transporter diseases.
We review the three genetically determined disorders of glucose transport across cell membranes. Diseases such as glucose-galactose malabsorption, Fanconi-Bickel syndrome and De Vivo disease (GLUT1 deficiency syndrome (GLUT1DS)) arise from heritable mutations in transporter-encoding genes that impair monosaccharide uptake, which becomes rate-limiting in tissues where the transporters serve as t...
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Glucose transporters (GLUTs) provide a pathway for glucose transport across membranes. Human GLUTs are implicated in devastating diseases such as heart disease, hyper- and hypo-glycemia, type 2 diabetes and cancer. The human GLUT1 has been recently crystalized in the inward-facing open conformation. However, there is no other structural information for other conformations. The X-ray structures ...
متن کاملRegulation of the glucose transporter GLUT1 in mammalian cells.
814 Regulation of the glucose transporter GLUT I in mammalian cells Stephen A. Baldwin*ll, On Kan*t, Anthony D. Whettont, Sally Martin$T, Hilary A. C. Fawcett*$, David J. Flint+ and Colin J. Wildet *Department of Biochemistry and Molecular Biology, University of Leeds, Leeds LS2 9JT, U.K., tDepartment of Biochemistry and Applied Molecular Biology, University of Manchester Institute of Science a...
متن کاملAssociation between coenzyme Q10 and glucose transporter (GLUT1) deficiency
BACKGROUND It has been demonstrated that glucose transporter (GLUT1) deficiency in a mouse model causes a diminished cerebral lipid synthesis. This deficient lipid biosynthesis could contribute to secondary CoQ deficiency. We report here, for the first time an association between GLUT1 and coenzyme Q10 deficiency in a pediatric patient. CASE PRESENTATION We report a 15 year-old girl with trun...
متن کاملProtein interactions with the glucose transporter binding protein GLUT1CBP that provide a link between GLUT1 and the cytoskeleton.
Subcellular targeting and the activity of facilitative glucose transporters are likely to be regulated by interactions with cellular proteins. This report describes the identification and characterization of a protein, GLUT1 C-terminal binding protein (GLUT1CBP), that binds via a PDZ domain to the C terminus of GLUT1. The interaction requires the C-terminal four amino acids of GLUT1 and is isof...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2006
ISSN: 0021-9258
DOI: 10.1074/jbc.m509422200